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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MT-ND4 is translated

MT-ND4 mRNA → MT-ND4

Reactome: R-HSA-9906955
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

MT-ND4 mRNAR-HSA-6793019, mitochondrial matrix

Outputs

MT-ND4R-HSA-60561, mitochondrial inner membrane

Catalysed by

membrane insertase activity of OXA1L:TMEM126A [mitochondrial inner membrane]

Literature

Knockdown of human Oxa1l impairs the biogenesis of F1Fo-ATP synthase and NADH:ubiquinone oxidoreductase J Mol Biol, 2007
Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria Mol Cell, 2024
NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate Cell Rep, 2021
Optic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I Proc Natl Acad Sci U S A, 2021