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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Intermediate 1 binds HP subcomplex to form Intermediate 2

HP subcomplex + Intermediate 1 → Intermediate 2

Reactome: R-HSA-6799178
Compartment: mitochondrial inner membrane
Rhea: None recorded

Inputs

HP subcomplexR-HSA-163929, mitochondrial inner membrane
Intermediate 1R-HSA-6788529, mitochondrial inner membrane

Outputs

Intermediate 2R-HSA-6799181, mitochondrial inner membrane

Literature

Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013
Assembly factors of human mitochondrial complex I and their defects in disease IUBMB Life, 2010
The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly Mol Cell Proteomics, 2020