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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH

CYC1:heme c + Intermediate II + UQCRC1 + UQCRC2 + UQCRH, (UQCRHL) → Late core complex monomer + UQCC3

Reactome: R-HSA-9866132
Compartment: mitochondrial inner membrane
Rhea: None recorded

Inputs

CYC1:heme cR-HSA-164584, mitochondrial inner membrane
Intermediate IIR-HSA-9866106, mitochondrial inner membrane
UQCRC1R-HSA-164284, mitochondrial inner membrane
UQCRC2R-HSA-164280, mitochondrial inner membrane
UQCRH, (UQCRHL)R-HSA-9932280, mitochondrial inner membrane

Outputs

Late core complex monomerR-HSA-9866126, mitochondrial inner membrane
UQCC3R-HSA-9866062, mitochondrial inner membrane

Catalysed by

protein binding activity of Intermediate II [mitochondrial inner membrane]

Literature

Biogenesis of the bc 1 Complex of the Mitochondrial Respiratory Chain J Mol Biol, 2018
Assembly of the Multi-Subunit Cytochrome bc 1 Complex in the Yeast Saccharomyces cerevisiae Int J Mol Sci, 2022
Architecture of Human Mitochondrial Respiratory Megacomplex I 2 III 2 IV 2 Cell, 2017
UQCRH downregulation promotes Warburg effect in renal cell carcinoma cells Sci Rep, 2020