Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2
NADH + 5 H+ + CoQ → NAD+ + 4 H+ + CoQH2
- Reactome
- R-HSA-163217
- Compartment
- mitochondrial inner membrane
- Rhea
- RHEA:29092
Inputs
- NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
- 5 H+CHEBI:15378, H, mitochondrial matrix
- CoQCHEBI:46245, C59H90O4, mitochondrial inner membrane
Outputs
- NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
- 4 H+CHEBI:15378, H, mitochondrial intermembrane space
- CoQH2CHEBI:64183, C59H92O4, mitochondrial inner membrane
Catalysed by
- NADH dehydrogenase (ubiquinone) activity of Complex I [mitochondrial inner membrane]EC 7.1.1.2
Literature
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: Biochem Biophys Res Commun, 1998
- The nuclear encoded subunits of complex I from bovine heart mitochondria Biochim Biophys Acta, 2003
- Structural organization of mitochondrial human complex I: role of the ND4 Biochem J, 2004
- The gross structure of the respiratory complex I: a Lego System Biochim Biophys Acta, 2004
- Human NADH:ubiquinone oxidoreductase J Bioenerg Biomembr, 2001
- The energy-transducing NADH: quinone oxidoreductase, complex I Mol Aspects Med, 2002