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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ND4, ND5 bind the 550kDa complex to form the 815kDa complex

550kDa complex + MT-ND4 + MT-ND5 → 815kDa complex

Reactome: R-HSA-6799197
Compartment: mitochondrial inner membrane
Rhea: None recorded

Inputs

550kDa complexR-HSA-6799176, mitochondrial inner membrane
MT-ND4R-HSA-60561, mitochondrial inner membrane
MT-ND5R-HSA-60565, mitochondrial inner membrane

Outputs

815kDa complexR-HSA-6799187, mitochondrial inner membrane

Literature

Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013
Assembly factors of human mitochondrial complex I and their defects in disease IUBMB Life, 2010
Accessory subunits are integral for assembly and function of human mitochondrial complex I Nature, 2016