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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

COX18 inserts nascent MT-CO2 in COX20:TMEM77

Mg2+ + COX20:TMEM177 + nascent MT-CO2 → MT-CO2:COX20:TMEM177

Reactome: R-HSA-9902096
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

Mg2+CHEBI:18420, Mg, mitochondrial matrix
COX20:TMEM177R-HSA-9865587, mitochondrial inner membrane
nascent MT-CO2R-HSA-9902095, mitochondrial matrix

Outputs

MT-CO2:COX20:TMEM177R-HSA-9865557, mitochondrial inner membrane

Catalysed by

membrane insertase activity of COX18 [mitochondrial inner membrane]UniProt Q8N8Q8

Literature

Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module J Biol Chem, 2017
A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia Hum Mol Genet, 2013
Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase Hum Mol Genet, 2014
The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis Biochim Biophys Acta Mol Cell Res, 2018