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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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PXLP-K259-GOT1 transaminates 2-OG and L-Asp

L-Asp + 2OG → OA + L-Glu

Reactome
R-HSA-70592
Compartment
cytosol
Rhea
RHEA:21825

Inputs

Outputs

Catalysed by

  • L-aspartate:2-oxoglutarate transaminase activity of PXLP-K259-GOT1 dimer [cytosol]EC 2.6.1.1

Literature

  1. The amino acid sequence of cytosolic aspartate aminotransferase from human liver Biochem J, 1990
  2. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors Biochemistry, 2018