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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUBPL transfers 4Fe-4S to Complex I subunits

NDUF subunits + NUBPL:4Fe-4S → NDUF:4Fe-4S subunits + NUBPL

Reactome: R-HSA-6788523
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

NDUF subunitsR-HSA-6788518, mitochondrial matrix
NUBPL:4Fe-4SR-HSA-5690007, mitochondrial matrix

Outputs

NDUF:4Fe-4S subunitsR-HSA-6788527, mitochondrial matrix
NUBPLR-HSA-5689133, mitochondrial matrix

Literature

Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013