MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
MT-CO3:PE:CL + NDUFA4:CL + COX7A1,2,2L + COX6A:PE + COX6B1,2 + holo-MT-CO1,2 complex → Cytochrome c oxidase + MITRAC
- Reactome
- R-HSA-9865663
- Compartment
- mitochondrial inner membrane
- Rhea
- None recorded
Inputs
- MT-CO3:PE:CLR-HSA-9864495, mitochondrial inner membrane
- NDUFA4:CLR-HSA-9864472, mitochondrial inner membrane
- COX7A1,2,2LR-HSA-5336144, mitochondrial inner membrane
- COX6A:PER-HSA-9864460, mitochondrial inner membrane
- COX6B1,2R-HSA-5336172, mitochondrial inner membrane
- holo-MT-CO1,2 complexR-HSA-9865576, mitochondrial inner membrane
Outputs
- Cytochrome c oxidaseR-HSA-164316, mitochondrial inner membrane
- MITRACR-HSA-9865338, mitochondrial inner membrane
Literature
- Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex Cell Metab., 2012
- Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis Cell Rep, 2020
- HIGD-Driven Regulation of Cytochrome c Oxidase Biogenesis and Function Cells, 2020
- HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV Mol Cell Proteomics, 2020
- Mitochondrial cytochrome c oxidase biogenesis: Recent developments Semin Cell Dev Biol, 2018
- Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis iScience, 2019