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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HCCS inserts heme into cytochrome c

heme b + apo-CYCS → Cytochrome c (reduced)

Reactome: R-HSA-9866217
Compartment: mitochondrial inner membrane
Rhea: RHEA:22650

Inputs

heme bCHEBI:26355, C34H32FeN4O4, mitochondrial inner membrane
apo-CYCSR-HSA-352608, mitochondrial inner membrane

Outputs

Cytochrome c (reduced)R-HSA-352609, mitochondrial inner membrane

Catalysed by

holocytochrome-c synthase activity of HCCS [mitochondrial inner membrane]EC 4.4.1.17; UniProt P53701

Literature

Human mitochondrial holocytochrome c synthase's heme binding, maturation determinants, and complex formation with cytochrome c Proc Natl Acad Sci U S A, 2013
Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome Am J Hum Genet, 2006