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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex

Intermediate 2 + MT-ND1 + NDUFAF5 + NDUFAF6 → 315kDa subcomplex

Reactome: R-HSA-6799191
Compartment: mitochondrial inner membrane
Rhea: None recorded

Inputs

Intermediate 2R-HSA-6799181, mitochondrial inner membrane
MT-ND1R-HSA-60551, mitochondrial inner membrane
NDUFAF5R-HSA-5689127, mitochondrial inner membrane
NDUFAF6R-HSA-5689130, mitochondrial inner membrane

Outputs

315kDa subcomplexR-HSA-6799189, mitochondrial inner membrane

Literature

Assembly factors for the membrane arm of human complex I Proc. Natl. Acad. Sci. U.S.A., 2013
Assembly factors of human mitochondrial complex I and their defects in disease IUBMB Life, 2010
Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function Mol Cell, 2016
A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis J Cell Biol, 2023
Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I Deficiency Am J Hum Genet, 2020
Defining mitochondrial protein functions through deep multiomic profiling Nature, 2022