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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

apo-UQCRFS1 binds LYRM7

LYRM7 + UQCRFS1(1-274) → UQCRFS1(1-274):LYRM7

Reactome: R-HSA-9866253
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

LYRM7R-HSA-9866252, mitochondrial matrix
UQCRFS1(1-274)R-HSA-9906006, mitochondrial matrix

Outputs

UQCRFS1(1-274):LYRM7R-HSA-9866263, mitochondrial matrix

Catalysed by

protein folding chaperone activity of LYRM7 [mitochondrial matrix]UniProt Q5U5X0

Literature

LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells Biochim Biophys Acta, 2013
Mitochondrial complex III Rieske Fe-S protein processing and assembly Cell Cycle, 2018
LYRM7-associated mitochondrial complex III deficiency with non-cavitating leukoencephalopathy and stroke-like episodes Am J Med Genet A, 2023
A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III Cell Metab, 2017