Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

2Fe-2S is inserted in UQCRFS1

FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster + UQCRFS1(1-274):LYRM7 → FXN:ISD11:NFS1:ISCU + holo-UQCRFS1(1-274) + LYRM7

Reactome: R-HSA-9866272
Compartment: mitochondrial inner membrane · mitochondrial matrix
Rhea: None recorded

Inputs

FXN:NFS1:ISD11:ISCU:2Fe-2S ClusterR-HSA-1362398, mitochondrial matrix
UQCRFS1(1-274):LYRM7R-HSA-9866263, mitochondrial matrix

Outputs

FXN:ISD11:NFS1:ISCUR-HSA-1362404, mitochondrial matrix
holo-UQCRFS1(1-274)R-HSA-164304, mitochondrial inner membrane
LYRM7R-HSA-9866252, mitochondrial matrix

Catalysed by

iron chaperone activity of FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix]

2Fe-2S is inserted in UQCRFS1

Inputs

Outputs

Catalysed by

Literature