Skip to content
DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
Data
100%

Loading the map…

Inositol phosphate metabolism

Phosphorylation, dephosphorylation and transport of inositol phosphates across cytosol, nucleus and endoplasmic reticulum. 71 reactions, from Reactome R-HSA-1483249.

  1. I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosolI(1,4,5)P3 + ATP → I(1,3,4,5)P4 + ADP + H+
  2. I1P is dephosphorylated to Ins by IMPA1/2 in the cytosolI1P + H2O → Ins + Pi
  3. I(1,3,4,5,6)P5 transports from the ER lumen to the cytosolI(1,3,4,5,6)P5 → I(1,3,4,5,6)P5
  4. 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus1-PP-IP5 + ATP + H+ → 1,5-(PP)2-IP4 + ADP
  5. 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol5-PP-IP5 + ATP → 5-PPP-IP5 + ADP
  6. I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosolI(1,3,4,6)P4 + H2O → I(3,4,6)P3 + Pi
  7. I(1,3,4,5,6)P5 transports from the ER lumen to the nucleusI(1,3,4,5,6)P5 → I(1,3,4,5,6)P5
  8. I(1,3,4,5,6)P5 transports from the nucleus to the cytosolI(1,3,4,5,6)P5 → I(1,3,4,5,6)P5
  9. I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosolI(3,4,5,6)P4 + ATP → I(1,3,4,5,6)P5 + ADP
  10. I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumenI(1,3,4,5,6)P5 + H2O → I(1,4,5,6)P4 + Pi
  11. IP6 transports from the cytosol to the ER lumenIP6 → IP6
  12. (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol(PP)2-IP4 + H2O → 5-PP-IP5 + Pi
  13. PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosolPP-IP4 + H2O → I(1,3,4,5,6)P5 + Pi
  14. I(1,3,4,5)P4 transports from the cytosol to the nucleusI(1,3,4,5)P4 → I(1,3,4,5)P4
  15. I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosolI(3,4,6)P3 + ATP → I(1,3,4,6)P4 + ADP + H+
  16. I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosolI(1,3,4,6)P4 + H2O → I(1,3,4)P3 + Pi
  17. I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosolI(1,3,4)P3 + ATP → I(1,3,4,5)P4 + ADP + H+
  18. 5-PP-IP4 transports from the nucleus to the cytosol5-PP-IP4 → 5-PP-IP4
  19. I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosolI(1,4,5)P3 + H2O → I(1,4)P2 + Pi
  20. I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleusI(1,3,4,5,6)P5 + ATP → IP6 + ADP + H+
  21. PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membranePI(4,5)P2 + H2O → DAG + I(1,4,5)P3 + H+
  22. Glc6P is isomerised to I3P by ISYNA1 in the cytosolGlc6P → I3P
  23. I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosolI(1,3,4,5,6)P5 + ATP → IP6 + ADP
  24. I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosolI(1,3,4)P3 + H2O → I(1,3)P2 + Pi
  25. I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleusI(1,3,4,5,6)P5 + ATP → 5-PP-IP4 + ADP
  26. 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol5-PP-IP5 + ATP → 1,5-(PP)2-IP4 + ADP
  27. I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleusI(1,4,5,6)P4 + ATP → I(1,3,4,5,6)P5 + ADP + H+
  28. I(1,3,4,5)P4 transports from the cytosol to the ER lumenI(1,3,4,5)P4 → I(1,3,4,5)P4
  29. IP6 transports from the nucleus to the ER lumenIP6 → IP6
  30. IP6 transports from the cytosol to the nucleusIP6 → IP6
  31. I(1,4,5,6)P4 transports from the ER lumen to the nucleusI(1,4,5,6)P4 → I(1,4,5,6)P4
  32. I(1,4,5)P3 transports from the cytosol to the nucleusI(1,4,5)P3 → I(1,4,5)P3
  33. 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol1-PP-IP4 + ATP → 1,5-(PP)2-IP3 + ADP
  34. 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol1-PP-IP5 + ATP → 1,5-(PP)2-IP4 + ADP
  35. I(1,3,4,5,6)P5 transports from the cytosol to the ER lumenI(1,3,4,5,6)P5 → I(1,3,4,5,6)P5
  36. I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosolI(1,3,4)P3 + ATP → I(1,3,4,6)P4 + ADP + H+
  37. 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol5-PP-IP5 + H2O → IP6 + Pi
  38. I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumenI(1,3,4,5)P4 + H2O → I(1,4,5)P3 + Pi
  39. I(1,3,4,6)P4 transports from the cytosol to the nucleusI(1,3,4,6)P4 → I(1,3,4,6)P4
  40. I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosolI(3,4)P2 + H2O → I3P + Pi
  41. 5-PP-IP5 transports from the nucleus to the cytosol5-PP-IP5 → 5-PP-IP5
  42. I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosolI(1,3,4,5)P4 + H2O → I(1,4,5)P3 + Pi
  43. I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleusI(1,3,4,5)P4 + ATP → I(1,3,4,5,6)P5 + ADP
  44. IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleusIP6 + ATP → 5-PP-IP5 + ADP
  45. I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosolI(1,4)P2 + H2O → I4P + Pi
  46. I3P is dephosphorylated to Ins by IMPA1/2 in the cytosolI3P + H2O → Ins + Pi
  47. I4P is dephosphorylated to Ins by IMPA1/2 in the cytosolI4P + H2O → Ins + Pi
  48. 1/3-PP-IP5 transports from the cytosol to the nucleus1/3-PP-IP5 → 1/3-PP-IP5
  49. I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membraneI(1,3,4,5)P4 + H2O → I(1,3,4)P3 + Pi
  50. PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membranePI(4,5)P2 + H2O → DAG + I(1,4,5)P3 + H+
  51. IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosolIP6 + ATP → 1-PP-IP5 + ADP
  52. I(1,4,5)P3 transports from the ER lumen to the cytosolI(1,4,5)P3 → I(1,4,5)P3
  53. I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosolI(1,3,4,5)P4 + H2O → I(1,3,4)P3 + Pi
  54. I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosolI(1,3,4,5,6)P5 + H2O → I(3,4,5,6)P4 + Pi
  55. (PP)2-IP4 transports from the nucleus to the cytosol(PP)2-IP4 → (PP)2-IP4
  56. PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membranePI(4,5)P2 + H2O → DAG + I(1,4,5)P3 + H+
  57. I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membraneI(1,4,5)P3 + H2O → I(1,4)P2 + Pi
  58. I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosolI(1,3,4,5,6)P5 + ATP → 5-PP-IP4 + ADP
  59. 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus5-PP-IP5 + ATP → 5-PPP-IP5 + ADP
  60. IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumenIP6 + H2O → I(1,2,4,5,6)P5 + Pi
  61. IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosolIP6 + ATP → 5-PP-IP5 + ADP
  62. I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleusI(1,3,4,6)P4 + ATP → I(1,3,4,5,6)P5 + ADP + H+
  63. 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus5-PP-IP4 + ATP → ADP + 1,5-(PP)2-IP3
  64. I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosolI(1,3,4)P3 + H2O → I(3,4)P2 + Pi
  65. I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleusI(1,4,5)P3 + ATP → I(1,3,4,5)P4 + ADP + H+
  66. 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol1/3-PP-IP5 + H2O → IP6 + Pi
  67. (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol(PP)2-IP4 + H2O → 1/3-PP-IP5 + Pi
  68. MIOX oxidises Ins to GlcAIns + O2 → GlcA + H2O + H+
  69. MTMR7 binds MTMR9MTMR7 + MTMR9 → MTMR7:MTMR9
  70. I(1,3)P2 is dephosphorylated into I1P by MTMR7I(1,3)P2 + H2O → I1P + Pi
  71. I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9I(1,3)P2 + H2O → Pi + I1P