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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus

I(1,3,4,5,6)P5 + ATP → 5-PP-IP4 + ADP

Reactome: R-HSA-1855181
Compartment: nucleoplasm
Rhea: None recorded

Inputs

I(1,3,4,5,6)P5CHEBI:57733, C6H7O21P5, nucleoplasm
ATPCHEBI:30616, C10H12N5O13P3, nucleoplasm

Outputs

5-PP-IP4CHEBI:142939, C6H7O24P6, nucleoplasm
ADPCHEBI:456216, C10H12N5O10P2, nucleoplasm

Catalysed by

inositol-1,3,4,5,6-pentakisphosphate kinase activity of IP6K1/2 [nucleoplasm]EC 2.7.4.21

Literature

Identification and characterization of a novel inositol hexakisphosphate kinase J Biol Chem, 2001
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis J Biol Chem, 2000
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups Chem Biol, 2008