Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus

I(1,3,4,5,6)P5 + ATP → IP6 + ADP + H+

Reactome: R-HSA-1855176
Compartment: nucleoplasm
Rhea: RHEA:20314

Inputs

I(1,3,4,5,6)P5CHEBI:57733, C6H7O21P5, nucleoplasm
ATPCHEBI:30616, C10H12N5O13P3, nucleoplasm

Outputs

IP6CHEBI:58130, C6H6O24P6, nucleoplasm
ADPCHEBI:456216, C10H12N5O10P2, nucleoplasm
H+CHEBI:15378, H, nucleoplasm

Catalysed by

inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity of IPPK [nucleoplasm]EC 2.7.1.158; UniProt Q9H8X2

I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus

Inputs

Outputs

Catalysed by

Literature