I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol

I(1,3,4,5)P4 + H2O → I(1,3,4)P3 + Pi

Reactome

R-HSA-1855218

Compartment

cytosol

Rhea

RHEA:11393

Catalysed by

• inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity of INPP5(3)/ITPK1 [cytosol]EC 3.1.3.56

Literature

1. Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase Curr Biol, 2002
2. Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation FEBS Lett, 2004
3. The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase J Biol Chem, 2002
4. Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase Biochem Biophys Res Commun, 1996
5. Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2 J Biol Chem, 2004
6. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 Curr Biol, 1996