Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen

I(1,3,4,5,6)P5 + H2O → I(1,4,5,6)P4 + Pi

Reactome: R-HSA-1855163
Compartment: endoplasmic reticulum lumen
Rhea: RHEA:77144

Inputs

I(1,3,4,5,6)P5CHEBI:57733, C6H7O21P5, endoplasmic reticulum lumen
H2OCHEBI:15377, H2O, endoplasmic reticulum lumen

Outputs

I(1,4,5,6)P4CHEBI:57627, C6H8O18P4, endoplasmic reticulum lumen
PiCHEBI:43474, HO4P, endoplasmic reticulum lumen

Catalysed by

inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity of MINPP1 [endoplasmic reticulum lumen]EC 3.1.3; UniProt Q9UNW1

I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen

Inputs

Outputs

Catalysed by

Literature