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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

I(1,3,4,5)P4 + H2O → I(1,4,5)P3 + Pi

Reactome
R-HSA-1855205
Compartment
cytosol
Rhea
RHEA:77156

Inputs

Outputs

Catalysed by

  • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity of PTEN:Mg2+ [cytosol]

Literature

  1. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J Biol Chem, 1998
  2. Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay Cancer Res, 2000