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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol

I(1,4,5)P3 + ATP → I(1,3,4,5)P4 + ADP + H+

Reactome: R-HSA-1855153
Compartment: cytosol
Rhea: RHEA:11021

Inputs

I(1,4,5)P3CHEBI:203600, C6H9O15P3, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

I(1,3,4,5)P4CHEBI:57895, C6H8O18P4, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

inositol-1,4,5-trisphosphate 3-kinase activity of active ITPKA/B/C [cytosol]EC 2.7.1.127

Literature

The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells Biochem J, 2003