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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol

I(1,3,4)P3 + H2O → I(3,4)P2 + Pi

Reactome: R-HSA-1855232
Compartment: cytosol
Rhea: RHEA:70320

Inputs

I(1,3,4)P3CHEBI:58414, C6H9O15P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

I(3,4)P2CHEBI:83241, C6H10O12P2, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

inositol-1,3,4-trisphosphate 1-phosphatase activity of INPP1:Mg2+ [cytosol]EC 3.1.3

Literature

Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase Proc Natl Acad Sci U S A, 1993