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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,3,4,5,6)P5 transports from the nucleus to the cytosol

I(1,3,4,5,6)P5 → I(1,3,4,5,6)P5

Reactome: R-HSA-1855161
Compartment: nucleoplasm · cytosol
Rhea: None recorded

Inputs

I(1,3,4,5,6)P5CHEBI:57733, C6H7O21P5, nucleoplasm

Outputs

I(1,3,4,5,6)P5CHEBI:57733, C6H7O21P5, cytosol

Catalysed by

narrow pore channel activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Literature

The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization Biochem J, 2002
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase Curr Biol, 2002
Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase Biochem J, 2007