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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol

I(3,4,5,6)P4 + ATP → I(1,3,4,5,6)P5 + ADP

Reactome: R-HSA-1855162
Compartment: cytosol
Rhea: RHEA:12453

Inputs

I(3,4,5,6)P4CHEBI:57539, C6H8O18P4, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

I(1,3,4,5,6)P5CHEBI:57733, C6H7O21P5, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol

Catalysed by

inositol-3,4,5,6-tetrakisphosphate 1-kinase activity of ITPK1:Mg2+ [cytosol]EC 2.7.1.134

Literature

Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase Biochem J, 2000