(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol

(PP)2-IP4 + H2O → 5-PP-IP5 + Pi

Reactome

R-HSA-1855165

Compartment

cytosol

Rhea

None recorded

Catalysed by

• inositol bisdiphosphate tetrakisphosphate diphosphatase activity of NUDT(1) [cytosol]EC 3.6.1.52

Literature

1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase J Biol Chem, 2002
2. The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein J Biol Chem, 1999
3. A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase EMBO J, 1998
4. Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates J Biol Chem, 1999
5. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family J Biol Chem, 2000
6. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases BMC Biochem, 2002