Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol

I(1,4)P2 + H2O → I4P + Pi

Reactome: R-HSA-1855208
Compartment: cytosol
Rhea: RHEA:15554

Inputs

I(1,4)P2CHEBI:58282, C6H10O12P2, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

I4PCHEBI:58469, C6H11O9P, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

inositol-1,4-bisphosphate 1-phosphatase activity of INPP1:Mg2+ [cytosol]EC 3.1.3.57

Literature

Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase Proc Natl Acad Sci U S A, 1993