I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 + H2O → I(1,4)P2 + Pi
- Reactome
- R-HSA-1855222
- Compartment
- plasma membrane · cytosol
- Rhea
- RHEA:19798
Inputs
- I(1,4,5)P3CHEBI:203600, C6H9O15P3, cytosol
- H2OCHEBI:15377, H2O, cytosol
Outputs
- I(1,4)P2CHEBI:58282, C6H10O12P2, cytosol
- PiCHEBI:43474, HO4P, cytosol
Catalysed by
- inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5A/B [plasma membrane]EC 3.1.3.56
Literature
- Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase J Biol Chem, 1994
- Properties of type II inositol polyphosphate 5-phosphatase J Biol Chem, 1995
- Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase J Biol Chem, 1991
- Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation FEBS Lett, 2004