5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol

5-PP-IP5 + H2O → IP6 + Pi

Reactome

R-HSA-1855198

Compartment

cytosol

Rhea

RHEA:22385

Catalysed by

• inositol diphosphate pentakisphosphate diphosphatase activity of NUDT(1) [cytosol]EC 3.6.1.52

Literature

1. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family J Biol Chem, 2000
2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases BMC Biochem, 2002
3. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase J Biol Chem, 2002
4. The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein J Biol Chem, 1999
5. A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase EMBO J, 1998
6. Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates J Biol Chem, 1999