I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol

I(1,4,5)P3 + H2O → I(1,4)P2 + Pi

Reactome

R-HSA-1855174

Compartment

cytosol

Rhea

RHEA:19798

Catalysed by

• inositol-1,4,5-trisphosphate 5-phosphatase activity of INPP5(4) [cytosol]EC 3.1.3.56

Literature

1. Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation FEBS Lett, 2004
2. Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles J Biol Chem, 1999
3. The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase Proc Natl Acad Sci U S A, 1995
4. Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate J Biol Chem, 1998