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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

I(1,3,4,5)P4 + H2O → I(1,3,4)P3 + Pi

Reactome: R-HSA-1855213
Compartment: plasma membrane · cytosol
Rhea: RHEA:11393

Inputs

I(1,3,4,5)P4CHEBI:57895, C6H8O18P4, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

I(1,3,4)P3CHEBI:58414, C6H9O15P3, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity of Inositol polyphosphate 5-phosphatase [plasma membrane]EC 3.1.3.56

Literature

Properties of type II inositol polyphosphate 5-phosphatase J Biol Chem, 1995
Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase J Biol Chem, 1991
Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation FEBS Lett, 2004