Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus

1-PP-IP5 + ATP + H+ → 1,5-(PP)2-IP4 + ADP

Reactome: R-HSA-1855157
Compartment: nucleoplasm
Rhea: RHEA:37468

Inputs

1-PP-IP5CHEBI:74946, C6H6O27P7, nucleoplasm
ATPCHEBI:30616, C10H12N5O13P3, nucleoplasm
H+CHEBI:15378, H, nucleoplasm

Outputs

1,5-(PP)2-IP4CHEBI:77983, C6H7O30P8, nucleoplasm
ADPCHEBI:456216, C10H12N5O10P2, nucleoplasm

Catalysed by

diphosphoinositol pentakisphosphate kinase activity of IP6K1/2 [nucleoplasm]

Literature

Identification and characterization of a novel inositol hexakisphosphate kinase J Biol Chem, 2001
A conserved family of enzymes that phosphorylate inositol hexakisphosphate Science, 2007