Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane

PI(4,5)P2 + H2O → DAG + I(1,4,5)P3 + H+

Reactome: R-HSA-1855214
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: RHEA:33179, RHEA:33180

Inputs

PI(4,5)P2CHEBI:58456, C11H14O19P3R2, endoplasmic reticulum membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

DAGCHEBI:17815, C5H6O5R2, endoplasmic reticulum membrane
I(1,4,5)P3CHEBI:203600, C6H9O15P3, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

phosphatidylinositol-4,5-bisphosphate phospholipase C activity of PL(C)D4:3xCa2+ [endoplasmic reticulum membrane]EC 3.1.4.11

PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane

Inputs

Outputs

Catalysed by

Literature