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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MIOX oxidises Ins to GlcA

Ins + O2 → GlcA + H2O + H+

Reactome: R-HSA-5678327
Compartment: cytosol
Rhea: RHEA:23697

Inputs

InsCHEBI:17268, C6H12O6, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

GlcACHEBI:58720, C6H9O7, cytosol
H2OCHEBI:15377, H2O, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

inositol oxygenase activity of MIOX:2xFe2+ [cytosol]EC 1.13.99.1

Literature

Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney Biochem. Biophys. Res. Commun., 2004
Structural and biophysical characterization of human myo-inositol oxygenase J. Biol. Chem., 2008