I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
I(1,4,5)P3 + ATP → I(1,3,4,5)P4 + ADP + H+
- Reactome
- R-HSA-1855233
- Compartment
- nucleoplasm
- Rhea
- RHEA:11021
Inputs
- I(1,4,5)P3CHEBI:203600, C6H9O15P3, nucleoplasm
- ATPCHEBI:30616, C10H12N5O13P3, nucleoplasm
Outputs
- I(1,3,4,5)P4CHEBI:57895, C6H8O18P4, nucleoplasm
- ADPCHEBI:456216, C10H12N5O10P2, nucleoplasm
- H+CHEBI:15378, H, nucleoplasm
Catalysed by
- inositol-1,4,5-trisphosphate 3-kinase activity of IPMK [nucleoplasm]EC 2.7.1.127; UniProt Q8NFU5
Literature
- The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization Biochem J, 2002
- The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase J Biol Chem, 2002
- Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate Biochem Biophys Res Commun, 2006