IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
IP6 + H2O → I(1,2,4,5,6)P5 + Pi
- Reactome
- R-HSA-1855225
- Compartment
- endoplasmic reticulum lumen
- Rhea
- RHEA:16990
Inputs
- IP6CHEBI:58130, C6H6O24P6, endoplasmic reticulum lumen
- H2OCHEBI:15377, H2O, endoplasmic reticulum lumen
Outputs
- I(1,2,4,5,6)P5CHEBI:57798, C6H7O21P5, endoplasmic reticulum lumen
- PiCHEBI:43474, HO4P, endoplasmic reticulum lumen
Catalysed by
- inositol hexakisphosphate 3-phosphatase activity of MINPP1 [endoplasmic reticulum lumen]EC 3.1.3.8; UniProt Q9UNW1
Literature
- Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity J Biol Chem, 1991
- The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification FEBS Lett, 1999
- Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19 Genomics, 1999
- Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) pool Cell Signal, 2006