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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus

I(1,4,5,6)P4 + ATP → I(1,3,4,5,6)P5 + ADP + H+

Reactome: R-HSA-1855185
Compartment: nucleoplasm
Rhea: RHEA:11857

Inputs

I(1,4,5,6)P4CHEBI:57627, C6H8O18P4, nucleoplasm
ATPCHEBI:30616, C10H12N5O13P3, nucleoplasm

Outputs

I(1,3,4,5,6)P5CHEBI:57733, C6H7O21P5, nucleoplasm
ADPCHEBI:456216, C10H12N5O10P2, nucleoplasm
H+CHEBI:15378, H, nucleoplasm

Catalysed by

inositol-1,4,5,6-tetrakisphosphate 3-kinase activity of IPMK [nucleoplasm]EC 2.7.1.151; UniProt Q8NFU5

Literature

The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization Biochem J, 2002
Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate Biochem Biophys Res Commun, 2006