PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 + H2O → DAG + I(1,4,5)P3 + H+
- Reactome
- R-HSA-1855177
- Compartment
- cytosol · plasma membrane
- Rhea
- RHEA:33180, RHEA:33179
Inputs
- PI(4,5)P2CHEBI:58456, C11H14O19P3R2, plasma membrane
- H2OCHEBI:15377, H2O, cytosol
Outputs
- DAGCHEBI:17815, C5H6O5R2, plasma membrane
- I(1,4,5)P3CHEBI:203600, C6H9O15P3, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- phosphatidylinositol-4,5-bisphosphate phospholipase C activity of PLCbz [cytosol]EC 3.1.4.11
Literature
- Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1) Biochim Biophys Acta, 2000
- Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily Eur J Biochem, 1992
- The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta J Biol Chem, 2005
- Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3 J Biol Chem, 1993
- cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4) Genomics, 1995
- Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes Reproduction, 2004