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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Peroxisomal lipid metabolism

Source-linked peroxisomal lipid reactions. 36 reactions, from Reactome R-HSA-390918.

  1. formyl-CoA + H2O => formate + CoASHFOR-CoA + H2O → CoA-SH + HCOOH
  2. ALDH3A2-2 oxidizes pristanal to pristanateNAD+ + Pristanal + H2O → pristanate + NADH + 2 H+
  3. 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA3S2HPhy-CoA → Pristanal + FOR-CoA
  4. phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphateATP + CoA-SH + Phytanate → AMP + Phytanoyl-CoA + PPi
  5. pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphateATP + CoA-SH + pristanate → AMP + (2R) Pristanoyl-CoA + PPi
  6. phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2Phytanoyl-CoA + 2OG + O2 → 3S2HPhy-CoA + SUCCA + CO2
  7. PMP34-mediated exchange of cytosolic ATP for peroxisomal AMPAMP + ATP → AMP + ATP
  8. ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA(2S) Pristanoyl-CoA + O2 → trans-2,3-dehydropristanoyl-CoA + H2O2
  9. (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)(2S) Pristanoyl-CoA + O2 → trans-2,3-dehydropristanoyl-CoA + H2O2
  10. Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA(2R) Pristanoyl-CoA → (2S) Pristanoyl-CoA
  11. trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoAtrans-2,3-dehydropristanoyl-CoA + H2O → 3-hydroxypristanoyl-CoA
  12. 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+3-hydroxypristanoyl-CoA + NAD+ → 3-ketopristanoyl-CoA + NADH + H+
  13. 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA3-ketopristanoyl-CoA + CoA-SH → 4,8,12-trimethyltridecanoyl-CoA + propionyl CoA
  14. 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA3-ketohexacosanoyl-CoA + CoA-SH → tetracosanoyl-CoA + Ac-CoA
  15. HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA3-hydroxyhexacosanoyl-CoA + NAD+ → 3-ketohexacosanoyl-CoA + NADH + H+
  16. HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoAtrans-2,3-dehydrohexacosanoyl-CoA + H2O → 3-hydroxyhexacosanoyl-CoA
  17. ACOX1 oxidizes C26:0 CoAC26:0 CoA + O2 → trans-2,3-dehydrohexacosanoyl-CoA + H2O2
  18. Conversion of 4,8,12-trimethyltridecanoyl-CoA to 4,8-dimethylnonanoyl-CoA4,8,12-trimethyltridecanoyl-CoA → 4,8-dimethylnonanoyl-CoA
  19. 4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH4,8-dimethylnonanoyl-CoA + CAR → 4,8-dimethylnonanoylcarnitine + CoA-SH
  20. propionyl-CoA + carnitine => propionylcarnitine + CoASHpropionyl CoA + CAR → Propionylcarnitine + CoA-SH
  21. acetyl-CoA + carnitine => acetylcarnitine + CoASHAc-CoA + CAR → ACAR + CoA-SH
  22. Beta-oxidation of tetradecenoyl-CoA to octanoyl-CoA8 CoA-SH + 8 H2O + 8 NAD+ + 8 O2 + tetracosanoyl-CoA → 8 Ac-CoA + 8 H+ + 8 H2O2 + 8 NADH + Octanoyl-CoA
  23. acetyl-CoA + H2O => acetate + CoASH + H+Ac-CoA + H2O → CH3COO- + CoA-SH + H+
  24. Peroxisomal uptake of very long-chain fatty acyl CoAVLCFA-CoA + 2 H2O + ATP → VLCFA + ADP + CoA-SH + 2 H+
  25. Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoAMCFA-CoA, LCFA-CoA + H2O → MCFA, LCFA + CoA-SH + H+
  26. DECR2 reduces a (2E,4E)-dienoyl-CoA to a 4,5-saturated-(3E)-enoyl-CoANADPH + H+ + (2E,4E)-dienoyl-CoA → NADP+ + 4,5-saturated-(3E)-enoyl-CoA(4-)
  27. HAO2 tetramer oxidises 2OH-PALM2OH-PALM + O2 → 2oxo-PALM + H2O2
  28. EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoAtrans-2,3-dehydrohexacosanoyl-CoA + H2O → 3-hydroxyhexacosanoyl-CoA
  29. EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA3-hydroxyhexacosanoyl-CoA + NAD+ → 3-ketohexacosanoyl-CoA + NADH + H+
  30. NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANTCoA-SH + H2O → PPANT + PAP + 2 H+
  31. ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA3Z-octenoyl-CoA → 2E-octenoyl-CoA
  32. PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA2E-phytenoyl-CoA + H+ + NADPH → NADP+ + Phytanoyl-CoA
  33. NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANTacyl-CoA + H2O → acyl-PPANT + PAP + 2 H+
  34. ACBD4,5 bind MCFA-CoA and LCFA-CoAACBD5,(ACBD4) + MCFA-CoA, LCFA-CoA → ACBD4,5:LCFA-CoA, MCFA-CoA
  35. malonyl-CoA is decarboxylated to acetyl-CoA in peroxisomeMalonyl-CoA + H+ → Ac-CoA + CO2
  36. SLC27A2-mediated ligation of peroxisomal fatty acid and CoASHATP + CoA-SH + VLCFA → AMP + PPi + VLCFA-CoA