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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Folate & pterines

Folate transport and interconversion of tetrahydrofolate-bound one-carbon units. 31 reactions, from Reactome R-HSA-196757.

  1. FPGS-2 transforms THF to THFPGTHF + 5 ATP + 5 L-Glu → THFPG + 5 ADP + 5 Pi
  2. DHFR2 reduces FOLA to DHFFOLA + NADPH + H+ → DHF + NADP+
  3. DHF is reduced to tetrahydrofolate (THF)DHF + NADPH + H+ → THF + NADP+
  4. 5,10-methyleneTHF polyglutamate + NADP+ 5,10-methenylTHF polyglutamate + NADPH + H+5,10-methylene-THFPG + NADP+ → 5,10-methenyl-THFPG + NADPH + H+
  5. Cytosolic folate export across the plasma membraneFOLA + H+ → FOLA + H+
  6. 5,10-methyleneTHF polyglutamate + glycine tetrahydrofolate polyglutamate (THF polyglutamate) + serine5,10-methylene-THFPG + Gly → THFPG + L-Ser
  7. SLC19A1 transports 5-methyl-THF from extracellular region to cytosol5-methyl-THF → 5-methyl-THF
  8. MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG10-formyl-THFPG → 5,10-methenyl-THFPG + H2O
  9. MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG5,10-methylene-THFPG + NADPH + H+ → 5-methyl-THFPG + NADP+
  10. SLC25A32 transports THF from cytosol to mitochondrial matrixTHF → THF
  11. FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG5-methyl-THF + 5 ATP + 5 L-Glu → 5-methyl-THFPG + 5 ADP + 5 Pi
  12. Mitochondrial FPGS-1 transforms THF to THFPGTHF + 6 ATP + 6 L-Glu → THFPG + 6 ADP + 6 Pi
  13. MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPGTHFPG + HCOOH + ATP → 10-formyl-THFPG + ADP + Pi
  14. MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG5,10-methenyl-THFPG + NADPH + H+ → 5,10-methylene-THFPG + NADP+
  15. SLC25A32 transports THF from mitochondrial matrix to cytosolTHF → THF
  16. SLC46A1 transports FOLA from extracellular region to cytosolFOLA + H+ → FOLA + H+
  17. SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPGTHFPG + L-Ser → 5,10-methylene-THFPG + Gly
  18. 5,10-methenylTHF polyglutamate + H2O 10-formylTHF polyglutamate5,10-methenyl-THFPG + H2O → 10-formyl-THFPG
  19. PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser5,10-methylene-THF + Gly + H2O → THF + L-Ser
  20. MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THFTHF + HCOOH + ATP → 10-formyl-THF + ADP + Pi
  21. MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF5,10-methylene-THF + NAD+ → 5,10-methenyl-THF + NADH
  22. MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG5-formyl-THFPG + ATP → 5,10-methenyl-THFPG + ADP + Pi + H+
  23. MTHFD1L transforms 10-formyl-THF to HCOOH and THF10-formyl-THF + Pi + ADP → HCOOH + THF + ATP
  24. MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF5,10-methenyl-THF + H2O → 10-formyl-THF
  25. HCOOH translocated from mitochondrial matrix to cytosolHCOOH → HCOOH
  26. ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG10-formyl-THFPG + NADP+ + H2O → THFPG + NADPH + H+ + CO2
  27. ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG10-formyl-THFPG + NADP+ + H2O → THFPG + NADPH + H+ + CO2
  28. FOLR2 binds FOLAFOLA + FOLR2 → FOLR2:FOLA
  29. FOLR2 transports FOLA from extracellular region to cytosolFOLR2:FOLA → FOLR2 + FOLA
  30. DHFR dimer reduces FOLA to DHFFOLA + NADPH + H+ → DHF + NADP+
  31. DHFR dimer binds DHFR inhibitorsDHFR dimer + DHFR inhibitors → DHFR dimer:DHFR inhibitors