FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG
5-methyl-THF + 5 ATP + 5 L-Glu → 5-methyl-THFPG + 5 ADP + 5 Pi
- Reactome
- R-HSA-200681
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- 5-methyl-THFCHEBI:18608, C20H23N7O6, cytosol
- 5 ATPCHEBI:30616, C10H12N5O13P3, cytosol
- 5 L-GluCHEBI:29985, C5H8NO4, cytosol
Outputs
- 5-methyl-THFPGCHEBI:63907, (C5H7NO3)n.C25H32N8O9, cytosol
- 5 ADPCHEBI:456216, C10H12N5O10P2, cytosol
- 5 PiCHEBI:43474, HO4P, cytosol
Catalysed by
- tetrahydrofolylpolyglutamate synthase activity of FPGS-2 [cytosol]EC 6.3.2.17; UniProt Q05932
Literature
- Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure Proc Natl Acad Sci U S A, 1992
- Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene J Biol Chem, 1996