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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG

THFPG + L-Ser → 5,10-methylene-THFPG + Gly

Reactome
R-HSA-200735
Compartment
cytosol
Rhea
None recorded

Inputs

Outputs

Catalysed by

  • aldehyde-lyase activity of SHMT1 tetramer [cytosol]EC 4.1.2

Literature

  1. The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy Structure, 1998