Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

5,10-methyleneTHF polyglutamate + NADP+ 5,10-methenylTHF polyglutamate + NADPH + H+

5,10-methylene-THFPG + NADP+ → 5,10-methenyl-THFPG + NADPH + H+

Reactome: R-HSA-200644
Compartment: cytosol
Rhea: None recorded

Inputs

5,10-methylene-THFPGCHEBI:60473, (C5H6NO3)n.C15H15N6O3, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

5,10-methenyl-THFPGCHEBI:65049, (C5H6NO3)n.C25H26N8O9, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

methylenetetrahydrofolate dehydrogenase (NADP+) activity of MTHFD1 dimer [cytosol]EC 1.5.1.5

5,10-methyleneTHF polyglutamate + NADP+ 5,10-methenylTHF polyglutamate + NADPH + H+

Inputs

Outputs

Catalysed by

Literature