MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF
5,10-methenyl-THF + H2O → 10-formyl-THF
- Reactome
- R-HSA-6801462
- Compartment
- mitochondrial matrix
- Rhea
- None recorded
Inputs
- 5,10-methenyl-THFCHEBI:57455, C20H20N7O6, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
Outputs
- 10-formyl-THFCHEBI:195366, C20H21N7O7, mitochondrial matrix
Catalysed by
- methylenetetrahydrofolate dehydrogenase (NAD+) activity of MTHFD2, D2L [mitochondrial matrix]EC 1.5.1.15
Literature
- Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues J. Biol. Chem., 2011
- Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues J. Biol. Chem., 2014
- NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene Biochemistry, 1993