ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG
10-formyl-THFPG + NADP+ + H2O → THFPG + NADPH + H+ + CO2
- Reactome
- R-HSA-6808487
- Compartment
- mitochondrial matrix
- Rhea
- None recorded
Inputs
- 10-formyl-THFPGCHEBI:28010, (C5H7NO3)n.C25H30N8O10, mitochondrial matrix
- NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
Outputs
- THFPGCHEBI:28624, (C5H7NO3)n.C19H23N7O6, mitochondrial matrix
- NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
- CO2CHEBI:16526, CO2, mitochondrial matrix
Catalysed by
- aldehyde dehydrogenase (NAD+) activity of ADH1L2 tetramer [mitochondrial matrix]EC 1.2.1.3
Literature
- ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase J. Biol. Chem., 2010
- Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase Chem. Biol. Interact., 2011