Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

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MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG

5,10-methenyl-THFPG + NADPH + H+ → 5,10-methylene-THFPG + NADP+

Reactome: R-HSA-200718
Compartment: cytosol
Rhea: None recorded

Inputs

5,10-methenyl-THFPGCHEBI:65049, (C5H6NO3)n.C25H26N8O9, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Outputs

5,10-methylene-THFPGCHEBI:60473, (C5H6NO3)n.C15H15N6O3, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

methylenetetrahydrofolate dehydrogenase (NADP+) activity of MTHFD1 dimer [cytosol]EC 1.5.1.5

MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG

Inputs

Outputs

Catalysed by

Literature