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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

10-formyl-THFPG + NADP+ + H2O → THFPG + NADPH + H+ + CO2

Reactome: R-HSA-6808496
Compartment: cytosol
Rhea: None recorded

Inputs

10-formyl-THFPGCHEBI:28010, (C5H7NO3)n.C25H30N8O10, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

THFPGCHEBI:28624, (C5H7NO3)n.C19H23N7O6, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
CO2CHEBI:16526, CO2, cytosol

Catalysed by

aldehyde dehydrogenase (NAD+) activity of ALDH1L1 tetramer [cytosol]EC 1.2.1.3

Literature

ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase J. Biol. Chem., 2010
Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase Chem. Biol. Interact., 2011