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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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DHFR dimer reduces FOLA to DHF

FOLA + NADPH + H+ → DHF + NADP+

Reactome
R-HSA-9709098
Compartment
cytosol
Rhea
RHEA:31105

Inputs

Outputs

Catalysed by

  • folate reductase activity of DHFR dimer [cytosol]

Literature

  1. The functional human dihydrofolate reductase gene J Biol Chem, 1984
  2. Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate Biochemistry, 1990