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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF

THF + HCOOH + ATP → 10-formyl-THF + ADP + Pi

Reactome: R-HSA-5696839
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

THFCHEBI:57453, C19H21N7O6, mitochondrial matrix
HCOOHCHEBI:15740, CHO2, mitochondrial matrix
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix

Outputs

10-formyl-THFCHEBI:195366, C20H21N7O7, mitochondrial matrix
ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
PiCHEBI:43474, HO4P, mitochondrial matrix

Catalysed by

formate-tetrahydrofolate ligase activity of MTHFD1L dimer [mitochondrial matrix]EC 6.3.4.3

Literature

Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls J. Biol. Chem., 2003
Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase Arch. Biochem. Biophys., 2005
Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos J. Biol. Chem., 2010