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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FOLR2 binds FOLA

FOLA + FOLR2 → FOLR2:FOLA

Reactome: R-HSA-8940134
Compartment: extracellular region · plasma membrane
Rhea: None recorded

Inputs

FOLACHEBI:62501, C19H17N7O6, extracellular region
FOLR2R-HSA-8940133, plasma membrane

Outputs

FOLR2:FOLAR-HSA-8940118, plasma membrane

Catalysed by

folic acid receptor activity of FOLR2 [plasma membrane]UniProt P14207

Literature

Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA Biochemistry, 1989
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition Proc. Natl. Acad. Sci. U.S.A., 2013
Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells J. Biol. Chem., 1985