Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG

THFPG + HCOOH + ATP → 10-formyl-THFPG + ADP + Pi

Reactome: R-HSA-200711
Compartment: cytosol
Rhea: None recorded

Inputs

THFPGCHEBI:28624, (C5H7NO3)n.C19H23N7O6, cytosol
HCOOHCHEBI:15740, CHO2, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

10-formyl-THFPGCHEBI:28010, (C5H7NO3)n.C25H30N8O10, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

formate-tetrahydrofolate ligase activity of MTHFD1 dimer [cytosol]EC 6.3.4.3

MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG

Inputs

Outputs

Catalysed by

Literature