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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC19A1 transports 5-methyl-THF from extracellular region to cytosol

5-methyl-THF → 5-methyl-THF

Reactome: R-HSA-200652
Compartment: plasma membrane
Rhea: None recorded

Inputs

5-methyl-THFCHEBI:18608, C20H23N7O6, extracellular region

Outputs

5-methyl-THFCHEBI:18608, C20H23N7O6, cytosol

Catalysed by

folic acid transmembrane transporter activity of SLC19A1 [plasma membrane]UniProt P41440

Literature

Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake J Biol Chem, 1995
Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion J Biol Chem, 1999